Again, Serena was the victor 7–6(4), 6–3 and the win moved Serena past her sister to the top of the rankings.Venus still led 5–4 in their head-to-head and 4–3 in Grand Slams, but it was now Serena who was seen as the player "now setting the agenda for women's tennis". Their fourth and last match of the year occurred in the final at the US Open, in a match where the victor would take not only the trophy but the No.1 ranking as well.
The win completed what has become popularly known as the "Serena Slam"; Serena Williams became the first player since Steffi Graf to hold all four Grand Slams at the same time.
In addition Venus Williams became the first player since Martina Hingis in 1997 to make four consecutive Grand Slam finals, and the sisters together became the first players in the open era to contest four consecutive finals at the majors. This consistent play at recent Grand Slams led some to remark that the Williams sisters had a stranglehold on women's tennis.
The only match between the Williams sisters during 2001 occurred in the final of the US Open, where they had never met but where both had previously won singles titles.
This was the first final involving sisters at a Grand Slam tournament during the open era and the first since the Watson sisters played in the 1884 Wimbledon final.
The Williams sisters next met in a repeat of the 2002 Wimbledon final.
Again the match was close but Serena, aided by an abdominal injury that negatively impacted Venus's speed, won 4–6, 6–4, 6–2.
Serena won the match 6–4, 6–3 with a "blistering" display of tennis.
2003 would be a year of injuries and loss for Venus and Serena Williams, with the two highlights being the Australian Open and Wimbledon finals.
At Roland Garros Serena beat Venus in a "tight" match 7–5, 6–3.
The Grand Slam was the first for Serena in three years, and it was the first final at the French Open ever played by sisters.
This match has been described as arguably "the most-anticipated tennis final in years".